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Neurology

📑 Journal Club Articles

Chorioamnionitis and Two-Year Outcomes in Infants with Hypoxic-Ischemic Encephalopathy.

Cornet MC, Gonzalez FF, Glass HC, Wu TW, Wisnowski JL, Li Y, Heagerty P, Juul SE, Wu YW.J Pediatr. 2024 Nov 20:114415. doi: 10.1016/j.jpeds.2024.114415. Online ahead of print.PMID: 39577760

Cooling and physiology during parent cuddling infants with neonatal encephalopathy in usual care: CoolCuddle-2 study.

Chakkarapani E, Ingram J, Stocks S, Beasant L, Odd D; CoolCuddle‐2 study research team.Acta Paediatr. 2024 Oct 25. doi: 10.1111/apa.17466. Online ahead of print.PMID: 39451123

Inpatient Skin-to-skin Care Predicts 12-Month Neurodevelopmental Outcomes in Very Preterm Infants.

Lazarus MF, Marchman VA, Brignoni-Pérez E, Dubner S, Feldman HM, Scala M, Travis KE.J Pediatr. 2024 Nov;274:114190. doi: 10.1016/j.jpeds.2024.114190. Epub 2024 Jul 14.PMID: 39004169

Clonidine as Monotherapy for Neonatal Opioid Withdrawal Syndrome: A Randomized Trial.

Bada HS, Westgate PM, Sithisarn T, Yolton K, Charnigo R, Pourcyrous M, Tang F, Gibson J, Shearer-Miller J, Giannone P, Leggas M.Pediatrics. 2024 Oct 15:e2023065610. doi: 10.1542/peds.2023-065610. Online ahead of print.PMID: 39403061

Antenatal magnesium sulphate reduces cerebral palsy after preterm birth, implementation into clinical practice needs to be accelerated globally to benefit preterm babies.

Luyt K.Cochrane Database Syst Rev. 2024 Sep 24;9:ED000168. doi: 10.1002/14651858.ED000168.PMID: 39315530 No abstract available.

Validation of a machine learning algorithm for identifying infants at risk of hypoxic ischaemic encephalopathy in a large unseen data set.

Murray AL, O'Boyle DS, Walsh BH, Murray DM.Arch Dis Child Fetal Neonatal Ed. 2024 Sep 24:fetalneonatal-2024-327366. doi: 10.1136/archdischild-2024-327366. Online ahead of print.PMID: 39251344

Quality Improvement Interventions to Prevent Intraventricular Hemorrhage: A Systematic Review.

Edwards EM, Ehret DEY, Cohen H, Zayack D, Soll RF, Horbar JD.Pediatrics. 2024 Jul 10:e2023064431. doi: 10.1542/peds.2023-064431. Online ahead of print.PMID: 38982935

The longitudinal assessment of prenatal cannabis use on neonatal outcomes.

Habersham LL, Hurd YL, Nomura Y.J Perinatol. 2024 Jun 18. doi: 10.1038/s41372-024-02027-w. Online ahead of print.PMID: 38890400

Early skin-to-skin contact and the risk of intraventricular haemorrhage and sepsis in preterm infants. 

Johansson MW, Lilliesköld S, Jonas W, Thernström Blomqvist Y, Skiöld B, Linnér A.Acta Paediatr. 2024 May 27. doi: 10.1111/apa.17302. Online ahead of print.PMID: 38803030

Esophageal versus Rectal Temperature Monitoring during Whole-body Therapeutic Hypothermia for Hypoxic-ischemic Encephalopathy: Association with Short and Long-term Outcomes. 

Wu TW, Schmicker R, Wood TR, Mietzsch U, Comstock B, Heagerty PJ, Rao R, Gonzalez F, Juul S, Wu YW.J Pediatr. 2024 Feb 1:113933. doi: 10.1016/j.jpeds.2024.113933. Online ahead of print.PMID: 38309524 Free article.

Daily skin-to-skin contact alters microbiota development in healthy full-term infants.

Eckermann HA, Meijer J, Cooijmans K, Lahti L, de Weerth C.Gut Microbes. 2024 Jan-Dec;16(1):2295403. doi: 10.1080/19490976.2023.2295403. Epub 2024 Jan 10.PMID: 38197254 Free PMC article. Clinical Trial.

Non-pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated neonates.

Pirlotte S, Beeckman K, Ooms I, Cools F.Cochrane Database Syst Rev. 2024 Jan 18;1(1):CD013353. doi: 10.1002/14651858.CD013353.pub2.PMID: 38235838

Early Hyperoxemia and 2-year Outcomes in Infants with Hypoxic-ischemic Encephalopathy: A Secondary Analysis of the Infant Cooling Evaluation (ICE) Trial. 

Badurdeen S, Cheong JLY, Donath S, Graham H, Hooper SB, Polglase GR, Jacobs S, Davis PG.J Pediatr. 2024 Jan 5:113902. doi: 10.1016/j.jpeds.2024.113902. Online ahead of print.PMID: 38185204 Free article.

Positioning for lumbar puncture in newborn infants. 

Pessano S, Bruschettini M, Prescott MG, Romantsik O.Cochrane Database Syst Rev. 2023 Dec 14;12(12):CD015592. doi: 10.1002/14651858.CD015592.pub3.PMID: 38096386 Review.

Feasibility and safety of sildenafil to repair brain injury secondary to birth asphyxia (SANE-01): A randomized, double-blind, placebo-controlled phase Ib clinical trial. 

Wintermark P, Lapointe A, Steinhorn R, Rampakakis E, Burhenne J, Meid AD, Bajraktari-Sylejmani G, Khairy M, Altit G, Adamo MT, Poccia A, Gilbert G, Saint-Martin C, Toffoli D, Vachon J, Hailu E, Colin P, Haefeli WE.J Pediatr. 2023 Dec 21:113879. doi: 10.1016/j.jpeds.2023.113879. Online ahead of print.PMID: 38142044 Free article.

Treatment of seizures in the neonate: Guidelines and consensus-based recommendations-Special report from the ILAE Task Force on Neonatal Seizures.

Pressler RM, Abend NS, Auvin S, Boylan G, Brigo F, Cilio MR, De Vries LS, Elia M, Espeche A, Hahn CD, Inder T, Jette N, Kakooza-Mwesige A, Mader S, Mizrahi EM, Moshé SL, Nagarajan L, Noyman I, Nunes ML, Samia P, Shany E, Shellhaas RA, Subota A, Triki CC, Tsuchida T, Vinayan KP, Wilmshurst JM, Yozawitz EG, Hartmann H. Epilepsia. 2023 Sep 1. doi: 10.1111/epi.17745. Online ahead of print.PMID: 37655702

To feed or not to feed during therapeutic hypothermia in asphyxiated neonates: a systematic review and meta-analysis.

Kumar J, Anne RP, Meena J, Sundaram V, Dutta S, Kumar P.Eur J Pediatr. 2023 Jun;182(6):2759-2773. doi: 10.1007/s00431-023-04950-0. Epub 2023 Apr 4.PMID: 37014443

EBNEO Commentary: Interventions to reduce severe brain injury risk in preterm neonates: A systematic review and meta-analysis.

Sewell E, Cohen SS.Acta Paediatr. 2023 Jul 21. doi: 10.1111/apa.16908. Online ahead of print.PMID: 37475595 No abstract available. -----

The Association of Dexamethasone and Hydrocortisone with Cerebellar Growth in Premature Infants.

Warmerdam LA, van Wezel-Meijler G, de Vries LS, Groenendaal F, Steggerda SJ.Neonatology. 2023 Jun 28:1-9. doi: 10.1159/000531075. Online ahead of print.PMID: 37379806 Free article.

Spontaneous resolution of post-hemorrhagic ventricular dilatation in preterm newborns and neurodevelopment.

Groulx-Boivin E, Paquette M, Khairy M, Beltempo M, Dudley R, Ferrand A, Guillot M, Bizgu V, Garfinkle J.Pediatr Res. 2023 May 13. doi: 10.1038/s41390-023-02647-6. Online ahead of print.PMID: 37179437

Efficacy of a Vibrating Crib Mattress to Reduce Pharmacologic Treatment in Opioid-Exposed Newborns: A Randomized Clinical Trial.

Bloch-Salisbury E, Wilson JD, Rodriguez N, Bruch T, McKenna L, Derbin M, Glidden B, Ayturk D, Aurora S, Yanowitz T, Barton B, Vining M, Beers SR, Bogen DL.JAMA Pediatr. 2023 Jul 1;177(7):665-674. doi: 10.1001/jamapediatrics.2023.1077.PMID: 37184872 Clinical Trial.

Differences between early and late MRI in infants with neonatal encephalopathy following therapeutic hypothermia.

Garvey AA, El-Shibiny H, Yang E, Inder TE, El-Dib M.Pediatr Res. 2023 Sep;94(3):1011-1017. doi: 10.1038/s41390-023-02580-8. Epub 2023 Apr 6.PMID: 37024670

Eat, Sleep, Console Approach or Usual Care for Neonatal Opioid Withdrawal.

Young LW, Ounpraseuth ST, Merhar SL, Hu Z, Simon AE, Bremer AA, Lee JY, Das A, Crawford MM, Greenberg RG, Smith PB, Poindexter BB, Higgins RD, Walsh MC, Rice W, Paul DA, Maxwell JR, Telang S, Fung CM, Wright T, Reynolds AM, Hahn DW, Ross J, McAllister JM, Crowley M, Shaikh SK, Puopolo KM, Christ L, Brown J, Riccio J, Wong Ramsey K, Akshatha, Braswell EF, Tucker L, McAlmon KR, Dummula K, Weiner J, White JR, Howell MP, Newman S, Snowden JN, Devlin LA; ACT NOW Collaborative.N Engl J Med. 2023 Jun 22;388(25):2326-2337. doi: 10.1056/NEJMoa2214470. Epub 2023 Apr 30.PMID: 37125831 Clinical Trial.

Neonatal Seizures.

Yozawitz E.N Engl J Med. 2023 May 4;388(18):1692-1700. doi: 10.1056/NEJMra2300188.PMID: 37133587 Review. No abstract available.

Cerebral Oximetry Monitoring in Extremely Preterm Infants.

Hansen ML, Pellicer A, Hyttel-Sørensen S, Ergenekon E, Szczapa T, Hagmann C, Naulaers G, Mintzer J, Fumagalli M, Dimitriou G, Dempsey E, Tkaczyk J, Cheng G, Fredly S, Heuchan AM, Pichler G, Fuchs H, Nesargi S, Hahn GH, Piris-Borregas S, Širc J, Alsina-Casanova M, Stocker M, Ozkan H, Sarafidis K, Hopper AO, Karen T, Rzepecka-Weglarz B, Oguz SS, Arruza L, Memisoglu AC, Del Rio Florentino R, Baserga M, Maton P, Truttmann AC, de Las Cuevas I, Agergaard P, Zafra P, Bender L, Lauterbach R, Lecart C, de Buyst J, El-Khuffash A, Curley A, Vaccarello OO, Miletin J, Papathoma E, Vesoulis Z, Vento G, Cornette L, Lopez LS, Yasa B, Klamer A, Agosti M, Baud O, Mastretta E, Cetinkaya M, McCall K, Zeng S, Hatzidaki E, Bargiel A, Marciniak S, Gao X, Huijia L, Chalak L, Yang L, Rao SA, Xu X, Gonzalez BL, Wilinska M, Yin Z, Sadowska-Krawczenko I, Serrano-Viñuales I, Krolak-Olejnik B, Ybarra MM, Morales-Betancourt C, Korček P, Teresa-Palacio M, Mosca F, Hergenhan A, Koksal N, Tsoni K, Kadri MM, Knöpfli C, Rafinska-Wazny E, Akin MS, Nordvik T, Peng Z, Kersin SG, Thewissen L, Alarcon A, Healy D, Urlesberger B, Baş M, Baumgartner J, Skylogianni E, Karadyova V, Valverde E, Bergon-Sendin E, Kucera J, Pison…See abstract for full author list ➔N Engl J Med. 2023 Apr 20;388(16):1501-1511. doi: 10.1056/NEJMoa2207554.PMID: 37075142 Clinical Trial.

Intraventricular Hemorrhage in Very Preterm Children: Mortality and Neurodevelopment at Age 5.

Tréluyer L, Chevallier M, Jarreau PH, Baud O, Benhammou V, Gire C, Marchand-Martin L, Marret S, Pierrat V, Ancel PY, Torchin H.Pediatrics. 2023 Apr 1;151(4):e2022059138. doi: 10.1542/peds.2022-059138.PMID: 36919442

Interventions to Reduce Severe Brain Injury Risk in Preterm Neonates: A Systematic Review and Meta-analysis.

Razak A, Patel W, Durrani NUR, Pullattayil AK.JAMA Netw Open. 2023 Apr 3;6(4):e237473. doi: 10.1001/jamanetworkopen.2023.7473.PMID: 37052920 Free PMC article.

Ondansetron to reduce neonatal opioid withdrawal severity a randomized clinical trial.

Peltz G, Jansson LM, Adeniyi-Jones S, Cohane C, Drover D, Shafer S, Wang M, Wu M, Govindaswami B, Jegatheesan P, Argani C, Khan S, Kraft WK.J Perinatol. 2023 Mar;43(3):271-276. doi: 10.1038/s41372-022-01487-2. Epub 2022 Aug 27.PMID: 36030327 Free PMC article. Clinical Trial.

Current pain management practices for preterm infants with necrotizing enterocolitis: a European survey.

Ten Barge JA, van den Bosch GE, Meesters NJ, Allegaert K, Arribas C, Cavallaro G, Garrido F, Raffaeli G, Vermeulen MJ, Simons SHP; ESPR Special Interest Group for Neonatal Pain and the NEC Pain Study Group.Pediatr Res. 2023 Aug;94(2):555-563. doi: 10.1038/s41390-023-02508-2. Epub 2023 Feb 24.PMID: 36828969 Free PMC article.

Antiseizure medication at discharge in infants with hypoxic-ischaemic encephalopathy: an observational study.

Sewell EK, Shankaran S, McDonald SA, Hamrick S, Wusthoff CJ, Adams-Chapman I, Chalak LF, Davis AS, Van Meurs K, Das A, Maitre N, Laptook A, Patel RM; National Institute of Child Health and Human Development Neonatal Research Network.Arch Dis Child Fetal Neonatal Ed. 2023 Jul;108(4):421-428. doi: 10.1136/archdischild-2022-324612. Epub 2023 Feb 2.PMID: 36732048

Acetaminophen Use During Pregnancy and Children's Risk of Autism, ADHD, and Intellectual Disability. 

Ahlqvist VH, Sjöqvist H, Dalman C, Karlsson H, Stephansson O, Johansson S, Magnusson C, Gardner RM, Lee BK.JAMA. 2024 Apr 9;331(14):1205-1214. doi: 10.1001/jama.2024.3172.PMID: 38592388

Vibration-based mitigation of noxious-evoked responses to skin puncture in neonates and infants: a randomised controlled trial. Relland LM, Kjeldsen CP, Jeanvoine A, Emery L, Adderley K, Srinivas R, McLoughlin M, Maitre NL.Arch Dis Child Fetal Neonatal Ed. 2024 Mar 13:fetalneonatal-2023-326588. doi: 10.1136/archdischild-2023-326588. Online ahead of print.PMID: 38479794

A phase I trial of caffeine to evaluate safety in infants with hypoxic-ischemic encephalopathy. 

Jackson W, Gonzalez D, Greenberg RG, Lee YZ, Laughon MM.J Perinatol. 2024 Apr;44(4):508-512. doi: 10.1038/s41372-023-01752-y. Epub 2023 Aug 16.PMID: 37587184 Clinical Trial.

Analysis of noise levels in the neonatal intensive care unit: the impact of clinical microsystems.

Fusch G, Mohamed S, Bakry A, Li EW, Dutta S, Helou SE, Fusch C.Eur J Pediatr. 2023 Dec 14. doi: 10.1007/s00431-023-05335-z. Online ahead of print.PMID: 38095715

Trial of Erythropoietin for Hypoxic-Ischemic Encephalopathy in Newborns.

Wu YW, Comstock BA, Gonzalez FF, Mayock DE, Goodman AM, Maitre NL, Chang T, Van Meurs KP, Lampland AL, Bendel-Stenzel E, Mathur AM, Wu TW, Riley D, Mietzsch U, Chalak L, Flibotte J, Weitkamp JH, Ahmad KA, Yanowitz TD, Baserga M, Poindexter BB, Rogers EE, Lowe JR, Kuban KCK, O'Shea TM, Wisnowski JL, McKinstry RC, Bluml S, Bonifacio S, Benninger KL, Rao R, Smyser CD, Sokol GM, Merhar S, Schreiber MD, Glass HC, Heagerty PJ, Juul SE; HEAL Consortium.N Engl J Med. 2022 Jul 14;387(2):148-159. doi: 10.1056/NEJMoa2119660.PMID: 35830641 Free PMC article. Clinical Trial.

Whole-Body Hypothermia vs Targeted Normothermia for Neonates With Mild Encephalopathy: A Multicenter Pilot Randomized Clinical Trial.

Montaldo P, Cirillo M, Burgod C, Caredda E, Ascione S, Carpentieri M, Puzone S, D'Amico A, Garegrat R, Lanza M, Moreno Morales M, Atreja G, Shivamurthappa V, Kariholu U, Aladangady N, Fleming P, Mathews A, Palanisami B, Windrow J, Harvey K, Soe A, Pattnayak S, Sashikumar P, Harigopal S, Pressler R, Wilson M, De Vita E, Shankaran S, Thayyil S; COMET Trial Group.JAMA Netw Open. 2024 May 1;7(5):e249119. doi: 10.1001/jamanetworkopen.2024.9119.PMID: 38709535 Free PMC article. Clinical Trial.

Feasibility of intranasal human milk as stem cell therapy in preterm infants with intraventricular hemorrhage.

Hoban R, Gallipoli A, Signorile M, Mander P, Gauthier-Fisher A, Librach C, Wilson D, Unger S.J Perinatol. 2024 Apr 30. doi: 10.1038/s41372-024-01982-8. Online ahead of print.PMID: 38688998

Therapeutic hypothermia for preterm infants 34-35 weeks gestational age with neonatal encephalopathy.

Kim SH, El-Shibiny H, Inder T, El-Dib M.J Perinatol. 2024 Jan 16. doi: 10.1038/s41372-024-01874-x. Online ahead of print.PMID: 38228763

Challenges in management of refractory pain and sedation in infants. 

Oschman A, Rao K.Front Pharmacol. 2024 Jan 3;14:1259064. doi: 10.3389/fphar.2023.1259064. eCollection 2023.PMID: 38235119 Free PMC article. Review.

Marijuana Use and Breastfeeding: A Survey of Newborn Nurseries. 

Chang PW, Goyal NK, Chung EK.Pediatrics. 2024 Jan 22:e2023063682. doi: 10.1542/peds.2023-063682. Online ahead of print.PMID: 38247374

Use of Dexmedetomidine and Opioids in Hospitalized Preterm Infants.

Curtis S, Kilpatrick R, Billimoria ZC, Zimmerman K, Tolia V, Clark R, Greenberg RG, Puia-Dumitrescu M.JAMA Netw Open. 2023 Nov 1;6(11):e2341033. doi: 10.1001/jamanetworkopen.2023.41033.PMID: 37921767 Free PMC article.

Characteristics, Genetic Testing, and Diagnoses of Infants with Neonatal Encephalopathy Not Due to Hypoxic Ischemic Encephalopathy: A Cohort Study.

Lenahan A, Mietzsch U, Wood TR, Callahan KP, Weiss EM, Miller DE, German K, Natarajan N, Puia-Dumitrescu M, Esposito V, Kolnik S, Law JB.J Pediatr. 2023 Jun 1;260:113533. doi: 10.1016/j.jpeds.2023.113533. Online ahead of print.PMID: 37269901

Development of a Bedside Tool to Predict the Diagnosis of Cerebral Palsy in Term-Born Neonates.

Rouabhi A, Husein N, Dewey D, Letourneau N, Daboval T, Oskoui M, Kirton A, Shevell M, Dunbar MJ; Canadian Cerebral Palsy Registry.JAMA Pediatr. 2023 Feb 1;177(2):177-186. doi: 10.1001/jamapediatrics.2022.5177.PMID: 36648921

Outcome at early school age and adolescence after hypothermia-treated hypoxic-ischaemic encephalopathy: an observational, population-based study.

Robertsson Grossmann K, Eriksson Westblad M, Blennow M, Lindström K.Arch Dis Child Fetal Neonatal Ed. 2023 May;108(3):295-301. doi: 10.1136/archdischild-2022-324418. Epub 2022 Dec 9.PMID: 36600485 Free PMC article.

Cumulative risk factors contributing to hearing loss in preterm infants.

Chant K, Bitner-Glindzicz M, Marlow N.Arch Dis Child Fetal Neonatal Ed. 2023 Sep;108(5):464-470. doi: 10.1136/archdischild-2022-324331. Epub 2022 Dec 23.PMID: 36564163

Effects of prophylactic indomethacin on morbidity and mortality in infants <25 weeks' gestation: a protocol driven intention to treat analysis.

Clyman RI, Hills NK.J Perinatol. 2022 Dec;42(12):1662-1668. doi: 10.1038/s41372-022-01547-7. Epub 2022 Oct 30.

Risk of seizures in neonates with hypoxic-ischemic encephalopathy receiving hypothermia plus erythropoietin or placebo.

Glass HC, Wusthoff CJ, Comstock BA, Numis AL, Gonzalez FF, Maitre N, Massey SL, Mayock DE, Mietzsch U, Natarajan N, Sokol GM, Bonifacio SL, Van Meurs KP, Thomas C, Ahmad KA, Heagerty PJ, Juul SE, Wu YW.Pediatr Res. 2023 Jul;94(1):252-259. doi: 10.1038/s41390-022-02398-w. Epub 2022 Dec 5.

Targeted screening for congenital cytomegalovirus infection: clinical, audiological and neuroimaging findings.

Chung PK, Schornagel F, Oudesluys-Murphy AM, de Vries LS, Soede W, van Zwet E, Vossen A.Arch Dis Child Fetal Neonatal Ed. 2023 May;108(3):302-308. doi: 10.1136/archdischild-2022-324699. Epub 2022 Dec 22.

Safety and Short-term Outcomes of High-Dose Erythropoietin in Preterm Infants With Intraventricular Hemorrhage: The EpoRepair Randomized Clinical Trial.

Wellmann S, Hagmann CF, von Felten S, Held L, Klebermass-Schrehof K, Truttmann AC, Knöpfli C, Fauchère JC, Bührer C, Bucher HU, Rüegger CM; Erythropoietin for the Repair of Cerebral Injury in Very Preterm Infants (EpoRepair) Investigators.JAMA Netw Open. 2022 Dec 1;5(12):e2244744. doi: 10.1001/jamanetworkopen.2022.44744.

Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.

Suarez EA, Huybrechts KF, Straub L, Hernández-Díaz S, Jones HE, Connery HS, Davis JM, Gray KJ, Lester B, Terplan M, Mogun H, Bateman BT.N Engl J Med. 2022 Dec 1;387(22):2033-2044. doi: 10.1056/NEJMoa2203318.

Relative Age and Psychotropic Drug Use in Preterm and Term-Born Children and Young Adults.

Bachmann CS, Risnes K, Bjørngaard JH, Schei J, Pape K.Pediatrics. 2022 Dec 1;150(6):e2022057085. doi: 10.1542/peds.2022-057085.

Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka, and Bangladesh.

Thayyil S, Pant S, Montaldo P, Shukla D, Oliveira V, Ivain P, Bassett P, Swamy R, Mendoza J, Moreno-Morales M, Lally PJ, Benakappa N, Bandiya P, Shivarudhrappa I, Somanna J, Kantharajanna UB, Rajvanshi A, Krishnappa S, Joby PK, Jayaraman K, Chandramohan R, Kamalarathnam CN, Sebastian M, Tamilselvam IA, Rajendran UD, Soundrarajan R, Kumar V, Sudarsanan H, Vadakepat P, Gopalan K, Sundaram M, Seeralar A, Vinayagam P, Sajjid M, Baburaj M, Murugan KD, Sathyanathan BP, Kumaran ES, Mondkar J, Manerkar S, Joshi AR, Dewang K, Bhisikar SM, Kalamdani P, Bichkar V, Patra S, Jiwnani K, Shahidullah M, Moni SC, Jahan I, Mannan MA, Dey SK, Nahar MN, Islam MN, Shabuj KH, Rodrigo R, Sumanasena S, Abayabandara-Herath T, Chathurangika GK, Wanigasinghe J, Sujatha R, Saraswathy S, Rahul A, Radha SJ, Sarojam MK, Krishnan V, Nair MK, Devadas S, Chandriah S, Venkateswaran H, Burgod C, Chandrasekaran M, Atreja G, Muraleedharan P, Herberg JA, Kling Chong WK, Sebire NJ, Pressler R, Ramji S, Shankaran S; HELIX consortium.Lancet Glob Health. 2021 Sep;9(9):e1273-e1285. doi: 10.1016/S2214-109X(21)00264-3. Epub 2021 Aug 3.

Effect of Treatment of Clinical Seizures vs Electrographic Seizures in Full-Term and Near-Term Neonates: A Randomized Clinical Trial.

Hunt RW, Liley HG, Wagh D, Schembri R, Lee KJ, Shearman AD, Francis-Pester S, deWaal K, Cheong JYL, Olischar M, Badawi N, Wong FY, Osborn DA, Rajadurai VS, Dargaville PA, Headley B, Wright I, Colditz PB; Newborn Electrographic Seizure Trial Investigators.JAMA Netw Open. 2021 Dec 1;4(12):e2139604. doi: 10.1001/jamanetworkopen.2021.39604.

Cannabis use during lactation may alter the composition of human breast milk.

Josan C, Shiplo S, Fusch G, Raha S, Shea AK.Pediatr Res. 2023 Jun;93(7):1959-1968. doi: 10.1038/s41390-022-02315-1. Epub 2022 Oct 4

The International League Against Epilepsy New Classification of Neonatal Seizures.

Mizrahi EM, Pressler RM; Task Force on Neonatal Seizures, Commission on Classification and Terminology, International League Against Epilepsy (ILAE).Pediatrics. 2022 Nov 1;150(5):e2022058114. doi: 10.1542/peds.2022-058114.

Ventricular Volume in Infants Born Very Preterm: Relationship with Brain Maturation and Neurodevelopment at Age 4.5 Years.

Sheng M, Guo T, Mabbott C, Chau V, Synnes A, de Vries LS, Grunau RE, Miller SP.J Pediatr. 2022 Sep;248:51-58.e2. doi: 10.1016/j.jpeds.2022.05.003. Epub 2022 May 11.

Neurological examination at 32-weeks postmenstrual age predicts 12-month cognitive outcomes in very preterm-born infants.

Huf IU, Baque E, Colditz PB, Chatfield MD, Ware RS, Boyd RN, George JM.Pediatr Res. 2023 May;93(6):1721-1727. doi: 10.1038/s41390-022-02310-6. Epub 2022 Sep 23.

Brain injury following mild hypoxic-ischemic encephalopathy in neonates-Ten-year experience in a tertiary perinatal center.

Imanishi T, Shimizu M, Sumiya W, Kanno C, Kanno M, Kanno M, Kawabata K.J Perinatol. 2022 Dec;42(12):1630-1636. doi: 10.1038/s41372-022-01486-3. Epub 2022 Aug 11.

Maternal acetaminophen use and cognitive development at 4 years: the Ontario Birth Study.

Lye JM, Knight JA, Arneja J, Seeto RA, Wong J, Adel Khani N, Brooks JD, Levitan RD, Matthews SG, Lye SJ, Hung RJ.Pediatr Res. 2023 Mar;93(4):959-963. doi: 10.1038/s41390-022-02182-w. Epub 2022 Jul 7.

Trial of Erythropoietin for Hypoxic-Ischemic Encephalopathy in Newborns.

Wu YW, Comstock BA, Gonzalez FF, Mayock DE, Goodman AM, Maitre NL, Chang T, Van Meurs KP, Lampland AL, Bendel-Stenzel E, Mathur AM, Wu TW, Riley D, Mietzsch U, Chalak L, Flibotte J, Weitkamp JH, Ahmad KA, Yanowitz TD, Baserga M, Poindexter BB, Rogers EE, Lowe JR, Kuban KCK, O'Shea TM, Wisnowski JL, McKinstry RC, Bluml S, Bonifacio S, Benninger KL, Rao R, Smyser CD, Sokol GM, Merhar S, Schreiber MD, Glass HC, Heagerty PJ, Juul SE; HEAL Consortium.N Engl J Med. 2022 Jul 14;387(2):148-159. doi: 10.1056/NEJMoa2119660.

Association of early cerebral oxygen saturation and brain injury in extremely preterm infants.

El-Dib M, Munster C, Sunwoo J, Cherkerzian S, Lee S, Hildrey E, Steele T, Bell K, Franceschini MA, Volpe JJ, Inder T.J Perinatol. 2022 Oct;42(10):1385-1391. doi: 10.1038/s41372-022-01447-w. Epub 2022 Jul 5.

Effects of prophylactic indomethacin on intraventricular hemorrhage and adverse outcomes in neonatal intensive care unit.

Miller CJ, Prusakov P, Magers J, Speaks S, Sacic H, Escobar K, Abdel-Rasoul M, Nelin LD.J Perinatol. 2022 Dec;42(12):1644-1648. doi: 10.1038/s41372-022-01441-2. Epub 2022 Jun 25.

Morphine versus methadone for neonatal opioid withdrawal syndrome: a randomized controlled pilot study.

Sutter MB, Watson H, Yonke N, Weitzen S, Leeman L.BMC Pediatr. 2022 Jun 15;22(1):345. doi: 10.1186/s12887-022-03401-3.

The effect of head positioning on brain tissue oxygenation in preterm infants: a randomized clinical trial study. Mohamammadie ZR, Ramezani M, Heidarzadeh M, Sezavar M, Saki A.J Perinatol. 2022 May;42(5):660-666. doi: 10.1038/s41372-022-01366-w. Epub 2022 Mar 24.

Association of multiple tracheal intubation attempts with clinical outcomes in extremely preterm infants: a retrospective single-center cohort study.

Miller KE, Singh N.J Perinatol. 2022 Sep;42(9):1216-1220. doi: 10.1038/s41372-022-01406-5. Epub 2022 Apr 26.

Dexmedetomidine affects cerebral activity in preterm infants.

Cortes-Ledesma C, Arruza L, Sainz-Villamayor A, Martínez-Orgado J.Arch Dis Child Fetal Neonatal Ed. 2023 May;108(3):316-318. doi: 10.1136/archdischild-2021-323411. Epub 2022 Mar 14.

Neurodevelopmental disorders and somatic diagnoses in a national cohort of children born before 24 weeks of gestation.

Morsing E, Lundgren P, Hård AL, Rakow A, Hellström-Westas L, Jacobson L, Johnson M, Nilsson S, Smith LEH, Sävman K, Hellström A.Acta Paediatr. 2022 Jun;111(6):1167-1175. doi: 10.1111/apa.16316. Epub 2022 Mar 22.

Impact of Carbon Dioxide on Cerebral Oxygenation and Vital Parameters in Stable Preterm and Term Infants Immediately after Birth.

Wolfsberger CH, Bruckner M, Schwaberger B, Mileder LP, Urlesberger B, Pichler G.Neonatology. 2022;119(1):10-17. doi: 10.1159/000519636. Epub 2021 Oct 28.

Birth Outcomes of Neonates Exposed to Marijuana in Utero: A Systematic Review and Meta-analysis.

Marchand G, Masoud AT, Govindan M, Ware K, King A, Ruther S, Brazil G, Ulibarri H, Parise J, Arroyo A, Coriell C, Goetz S, Karrys A, Sainz K. JAMA Netw Open. 2022 Jan 4;5(1):e2145653. doi: 10.1001/jamanetworkopen.2021.45653.

Association of umbilical cord blood gas values with mortality and severe neurologic injury in preterm neonates <29 weeks' gestation: a national cohort study.

Shah PS, Barrett J, Claveau M, Cieslak Z, Makary H, Monterrosa L, Sherlock R, Yang J, McDonald SD; Canadian Neonatal Network; Canadian Preterm Birth Network Investigators.Am J Obstet Gynecol. 2022 Jul;227(1):85.e1-85.e10. doi: 10.1016/j.ajog.2022.01.001. Epub 2022 Jan 6.

Kangaroo mother care had a protective effect on the volume of brain structures in young adults born preterm.

Charpak N, Tessier R, Ruiz JG, Uriza F, Hernandez JT, Cortes D, Montealegre-Pomar A.Acta Paediatr. 2022 May;111(5):1004-1014. doi: 10.1111/apa.16265. Epub 2022 Feb 1.

Physiological responses to cuddling babies with hypoxic-ischaemic encephalopathy during therapeutic hypothermia: an observational study.

Odd D, Okano S, Ingram J, Blair PS, Billietop A, Fleming PJ, Thoresen M, Chakkarapani E.BMJ Paediatr Open. 2021 Dec;5(1):e001280. doi: 10.1136/bmjpo-2021-001280. Epub 2021 Dec 16.

Outcomes of neonatal hypoxic-ischaemic encephalopathy in centres with and without active therapeutic hypothermia: a nationwide propensity score-matched analysis.

Shipley L, Mistry A, Sharkey D.Arch Dis Child Fetal Neonatal Ed. 2022 Jan;107(1):6-12. doi: 10.1136/archdischild-2020-320966. Epub 2021 May 27.

Visual tracking at 4 months in preterm infants predicts 6.5-year cognition and attention.

Kaul YF, Rosander K, von Hofsten C, Strand Brodd K, Holmström G, Hellström-Westas L.Pediatr Res. 2022 Oct;92(4):1082-1089. doi: 10.1038/s41390-021-01895-8. Epub 2021 Dec 23.

Sex Differences in the Association of Pretransfusion Hemoglobin Levels with Brain Structure and Function in the Preterm Infant.

Benavides A, Bell EF, Conrad AL, Feldman HA, Georgieff MK, Josephson CD, Koscik TR, Stowell SR, Sola-Visner M, Nopoulos P.J Pediatr. 2022 Apr;243:78-84.e5. doi: 10.1016/j.jpeds.2021.12.051. Epub 2021 Dec 27.

Early arterial pressure monitoring and term-equivalent age MRI findings in very preterm infants.

Butticci R, Habre C, Hernandez A, Barcos-Munoz F, Pfister R, Hanquinet S, Beuchée A, Baud O.Pediatr Res. 2022 Sep;92(3):822-828. doi: 10.1038/s41390-021-01839-2. Epub 2021 Nov 19.

Cerebral perfusion and neurological examination characterise neonatal opioid withdrawal syndrome: a prospective cohort study.

Benninger KL, Peng J, Ho ML, Newton J, Wang DJJ, Hu HH, Stark AR, Rusin JA, Maitre NL.Arch Dis Child Fetal Neonatal Ed. 2022 Jul;107(4):414-420. doi: 10.1136/archdischild-2021-322192. Epub 2021 Nov 1.

Neurodevelopmental Outcomes following Intrauterine Growth Restriction and Very Preterm Birth.

Sacchi C, O'Muircheartaigh J, Batalle D, Counsell SJ, Simonelli A, Cesano M, Falconer S, Chew A, Kennea N, Nongena P, Rutherford MA, Edwards AD, Nosarti C.J Pediatr. 2021 Nov;238:135-144.e10. doi: 10.1016/j.jpeds.2021.07.002. Epub 2021 Jul 8.PMID: 34245768

Associations between Neonatal Magnetic Resonance Imaging and Short- and Long-Term Neurodevelopmental Outcomes in a Longitudinal Cohort of Very Preterm Children.

Jansen L, van Steenis A, van den Berg-Huysmans AA, Wiggers-de Bruine ST, Rijken M, de Vries LS,

Vermeiren RRJM, Peeters-Scholte CMPCD, Steggerda SJ.J Pediatr. 2021 Jul;234:46-53.e2. doi: 10.1016/j.jpeds.2021.02.005. Epub 2021 Feb 10.

Positive fluid balance is associated with death and severity of brain injury in neonates with hypoxic-ischemic encephalopathy.

Ottolini KM, Basu SK, Herrera N, Govindan V, Mashat S, Vezina G, Ridore M, Bost J, Chang T, Massaro AN.J Perinatol. 2021 Jun;41(6):1331-1338. doi: 10.1038/s41372-021-00988-w. Epub 2021 Mar 1.PMID: 33649446 Free PMC article.

Effect of prenatal marijuana exposure on sleep wake cycles and amplitude-integrated electroencephalogram (aEEG).

Pollack R, Rana D, Purvis J, Pollard L, Pourcyrous M.J Perinatol. 2021 Jun;41(6):1355-1363. doi: 10.1038/s41372-020-00911-9. Epub 2021 Jan 18.PMID: 33462338

Blood biomarkers for neonatal hypoxic-ischemic encephalopathy in the presence and absence of sentinel events.

Broni EK, Eke AC, Vaidya D, Tao X, Northington FJ, Everett AD, Graham EM.J Perinatol. 2021 Jun;41(6):1322-1330. doi: 10.1038/s41372-020-00850-5. Epub 2020 Oct 6.PMID: 33024259 Free PMC article.

Darbepoetin as a neuroprotective agent in mild neonatal encephalopathy: a randomized, placebo-controlled, feasibility trial.

DuPont TL, Baserga M, Lowe J, Zamora T, Beauman S, Ohls RK.J Perinatol. 2021 Jun;41(6):1339-1346. doi: 10.1038/s41372-021-01081-y. Epub 2021 May 13.PMID: 33986477 Free PMC article. Clinical Trial.

Using buprenorphine to treat neonatal abstinence syndrome: a quality improvement study.

Bhandary S, Lambeth T, Holmes A, Pylipow M.J Perinatol. 2021 Jun;41(6):1480-1486. doi: 10.1038/s41372-021-01035-4. Epub 2021 Mar 23.PMID: 33758394

Neonatology Review 

#260 - 🧠 Neurology - Questions 50, 51, 56 - Hypotonia, hearing loss, neural tube defects

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