Hematology / Oncology

📑 Journal Club Articles

Feasibility and safety of autologous cord blood derived cell administration in extremely preterm infants: a single-centre, open-label, single-arm, phase I trial (CORD-SaFe study).

Zhou L, McDonald CA, Yawno T, Razak A, Connelly K, Novak I, Miller SL, Jenkin G, Malhotra A.EBioMedicine. 2024 Dec 13;111:105492. doi: 10.1016/j.ebiom.2024.105492. Online ahead of print.PMID: 39674685 Free article.

Most major bleeds in preterm infants occur in the absence of severe thrombocytopenia: an observational cohort study.

van der Staaij H, Hooiveld NMA, Caram-Deelder C, Fustolo-Gunnink SF, Fijnvandraat K, Steggerda SJ, de Vries LS, van der Bom JG, Lopriore E.Arch Dis Child Fetal Neonatal Ed. 2024 Jul 15:fetalneonatal-2024-326959. doi: 10.1136/archdischild-2024-326959. Online ahead of print.PMID: 39009429

Fetal haemoglobin and oxygen requirement in preterm infants: an observational study.

Ulinder T, Hellström W, Gadsbøll C, Nilsson L, Gebka M, Robertz G, Bruschettini M, Hellstrom A, Ley D.Arch Dis Child Fetal Neonatal Ed. 2024 Sep 25:fetalneonatal-2024-327411. doi: 10.1136/archdischild-2024-327411. Online ahead of print.PMID: 39322316

Clinical Practice Guideline for Red Blood Cell Transfusion Thresholds in Very Preterm Neonates.

Deschmann E, Dame C, Sola-Visner MC, Fustolo-Gunnink SF, Guyatt GH, Patel RM, Stanworth SJ; Neonatal Transfusion Network.JAMA Netw Open. 2024 Jun 3;7(6):e2417431. doi: 10.1001/jamanetworkopen.2024.17431.PMID: 38874929 Free article

Timing of Red Blood Cell Transfusions and Occurrence of Necrotizing Enterocolitis: A Secondary Analysis of a Randomized Clinical Trial.

Salas AA, Gunn E, Carlo WA, Bell EF, Das A, Josephson CD, Patel RM, Tan S, Kirpalani H; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network. JAMA Netw Open. 2024 May 1;7(5):e249643. doi: 10.1001/jamanetworkopen.2024.9643.

PMID: 38700862

Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study.

Ohuma EO, Jabin N, Young MF, Epie T, Martorell R, Peña-Rosas JP, Garcia-Casal MN; INTERBIO-21st Consortium; Papageorghiou AT, Kennedy SH, Villar J.Lancet Haematol. 2023 Sep;10(9):e756-e766. doi: 10.1016/S2352-3026(23)00170-9. Epub 2023 Jul 20.PMID: 37482061 Free article.

Two-year outcomes following a randomised platelet transfusion trial in preterm infants.

Moore CM, D'Amore A, Fustolo-Gunnink S, Hudson C, Newton A, Santamaria BL, Deary A, Hodge R, Hopkins V, Mora A, Llewelyn C, Venkatesh V, Khan R, Willoughby K, Onland W, Fijnvandraat K, New HV, Clarke P, Lopriore E, Watts T, Stanworth S, Curley A; PlaNeT2 MATISSE.Arch Dis Child Fetal Neonatal Ed. 2023 Sep;108(5):452-457. doi: 10.1136/archdischild-2022-324915. Epub 2023 Feb 21.PMID: 36810309 Free PMC article.

Platelet Transfusions in a Multi-Neonatal Intensive Care Unit Health Care Organization Before and After Publication of the PlaNeT-2 Clinical Trial.

Bahr TM, Christensen TR, Henry E, Astin M, Ilstrup SJ, Ohls RK, Christensen RD.J Pediatr. 2023 Jun;257:113388. doi: 10.1016/j.jpeds.2023.03.003. Epub 2023 Mar 16.

Two-year outcomes following a randomised platelet transfusion trial in preterm infants.

Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults.

Bosch de Basea Gomez M, Thierry-Chef I, Harbron R, Hauptmann M, Byrnes G, Bernier MO, Le Cornet L, Dabin J, Ferro G, Istad TS, Jahnen A, Lee C, Maccia C, Malchair F, Olerud H, Simon SL, Figuerola J, Peiro A, Engels H, Johansen C, Blettner M, Kaijser M, Kjaerheim K, Berrington de Gonzalez A, Journy N, Meulepas JM, Moissonnier M, Nordenskjold A, Pokora R, Ronckers C, Schüz J, Kesminiene A, Cardis E.Nat Med. 2023 Nov 9. doi: 10.1038/s41591-023-02620-0. Online ahead of print.PMID: 37946058

Trial of Erythropoietin for Hypoxic-Ischemic Encephalopathy in Newborns.

Wu YW, Comstock BA, Gonzalez FF, Mayock DE, Goodman AM, Maitre NL, Chang T, Van Meurs KP, Lampland AL, Bendel-Stenzel E, Mathur AM, Wu TW, Riley D, Mietzsch U, Chalak L, Flibotte J, Weitkamp JH, Ahmad KA, Yanowitz TD, Baserga M, Poindexter BB, Rogers EE, Lowe JR, Kuban KCK, O'Shea TM, Wisnowski JL, McKinstry RC, Bluml S, Bonifacio S, Benninger KL, Rao R, Smyser CD, Sokol GM, Merhar S, Schreiber MD, Glass HC, Heagerty PJ, Juul SE; HEAL Consortium.N Engl J Med. 2022 Jul 14;387(2):148-159. doi: 10.1056/NEJMoa2119660.PMID: 35830641 Free PMC article. Clinical Trial.

Erythropoietin and retinopathy of prematurity: a retrospective cohort study in Japan, 2008-2018.

Fukui K, Ito Y, Kokubo M, Nakanishi H, Hirano S, Kusuda S, Ito S, Isayama T; Neonatal Research Network of Japan.J Perinatol. 2024 Mar 21. doi: 10.1038/s41372-024-01929-z. Online ahead of print.PMID: 38514743

Platelet Transfusion and Death or Neurodevelopmental Impairment in Children Born Extremely Preterm.

Davenport PE, Wood TR, Heagerty PJ, Sola-Visner MC, Juul SE, Patel RM.JAMA Netw Open. 2024 Jan 2;7(1):e2352394. doi: 10.1001/jamanetworkopen.2023.52394.PMID: 38261320 Free

Can Red Blood Cell and Platelet Transfusions Have a Pathogenic Role in Bronchopulmonary Dysplasia?

Bahr TM, Snow GL, Christensen TR, Davenport P, Henry E, Tweddell SM, Ilstrup SJ, Yoder BA, Ohls RK, Sola-Visner MC, Christensen RD.J Pediatr. 2023 Nov 20;265:113836. doi: 10.1016/j.jpeds.2023.113836. Online ahead of print.PMID: 37992802

Tissue Oxygenation Changes After Transfusion and Outcomes in Preterm Infants: A Secondary Near-Infrared Spectroscopy Study of the Transfusion of Prematures Randomized Clinical Trial (TOP NIRS).

Chock VY, Kirpalani H, Bell EF, Tan S, Hintz SR, Ball MB, Smith E, Das A, Loggins YC, Sood BG, Chalak LF, Wyckoff MH, Kicklighter SD, Kennedy KA, Patel RM, Carlo WA, Johnson KJ, Watterberg KL, Sánchez PJ, Laptook AR, Seabrook RB, Cotten CM, Mancini T, Sokol GM, Ohls RK, Hibbs AM, Poindexter BB, Reynolds AM, DeMauro SB, Chawla S, Baserga M, Walsh MC, Higgins RD, Van Meurs KP; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.JAMA Netw Open. 2023 Sep 5;6(9):e2334889. doi: 10.1001/jamanetworkopen.2023.34889.PMID: 37733345 Free PMC article. Clinical Trial.

Does donor sex influence the potential for transfusion with washed packed red blood cells to limit transfusion-related immune responses in preterm newborns?

Crawford T, Andersen C, Marks DC, Robertson SA, Stark M.Arch Dis Child Fetal Neonatal Ed. 2023 Sep;108(5):471-477. doi: 10.1136/archdischild-2022-324531. Epub 2023 Jan 23.PMID: 36690436

Effect of washed versus unwashed red blood cells on transfusion-related immune responses in preterm newborns.

Crawford TM, Andersen CC, Hodyl NA, Robertson SA, Stark MJ.Clin Transl Immunology. 2022 Mar 9;11(3):e1377. doi: 10.1002/cti2.1377. eCollection 2022.PMID: 35284073

Safety and Short-term Outcomes of High-Dose Erythropoietin in Preterm Infants With Intraventricular Hemorrhage: The EpoRepair Randomized Clinical Trial.

Wellmann S, Hagmann CF, von Felten S, Held L, Klebermass-Schrehof K, Truttmann AC, Knöpfli C, Fauchère JC, Bührer C, Bucher HU, Rüegger CM; Erythropoietin for the Repair of Cerebral Injury in Very Preterm Infants (EpoRepair) Investigators.JAMA Netw Open. 2022 Dec 1;5(12):e2244744. doi: 10.1001/jamanetworkopen.2022.44744.

Nipocalimab in Early-Onset Severe Hemolytic Disease of the Fetus and Newborn.

Moise KJ Jr, Ling LE, Oepkes D, Tiblad E, Verweij EJTJ, Lopriore E, Smoleniec J, Sachs UJ, Bein G, Kilby MD, Miller RS, Devlieger R, Audibert F, Emery SP, Markham K, Norton ME, Ocón-Hernández O, Pandya P, Pereira L, Silver RM, Windrim R, Streisand JB, Leu JH, Mirza A, Smith V, Schwartz LB, Tjoa ML, Saeed-Khawaja S, Komatsu Y, Bussel JB; UNITY Study Group.N Engl J Med. 2024 Aug 8;391(6):526-537. doi: 10.1056/NEJMoa2314466.PMID: 39115062 Clinical Trial.

Association between neonatal phototherapy and future cancer: an updated systematic review and meta-analysis.

Abdellatif M, Tawfik GM, Makram AM, Abdelsattar MK, Dobs M, Papadopoulos DN, Hoang-Trong BL, Mostafa EM, Duong PDT, Huy NT.Eur J Pediatr. 2023 Jan;182(1):329-341. doi: 10.1007/s00431-022-04675-6. Epub 2022 Nov 10.

Higher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants.

Kirpalani H, Bell EF, Hintz SR, Tan S, Schmidt B, Chaudhary AS, Johnson KJ, Crawford MM, Newman JE, Vohr BR, Carlo WA, D'Angio CT, Kennedy KA, Ohls RK, Poindexter BB, Schibler K, Whyte RK, Widness JA, Zupancic JAF, Wyckoff MH, Truog WE, Walsh MC, Chock VY, Laptook AR, Sokol GM, Yoder BA, Patel RM, Cotten CM, Carmen MF, Devaskar U, Chawla S, Seabrook R, Higgins RD, Das A; Eunice Kennedy Shriver NICHD Neonatal Research Network.N Engl J Med. 2020 Dec 31;383(27):2639-2651. doi: 10.1056/NEJMoa2020248.

Trial of Erythropoietin for Hypoxic-Ischemic Encephalopathy in Newborns.

Postdischarge Iron Status in Very Preterm Infants Receiving Prophylactic Iron Supplementation after Birth.

Landry C, Dorling J, Kulkarni K, Campbell-Yeo M, Morrison L, Ledwidge J, Vincer M, Ghotra S.J Pediatr. 2022 Aug;247:74-80.e2. doi: 10.1016/j.jpeds.2022.04.050. Epub 2022 May 14.

Erythropoietin for preventing bronchopulmonary dysplasia in preterm infants: A systematic review and meta-analysis.

Li J, Zhang J, Hao Q, Chen H, Cheng X.Pediatr Pulmonol. 2022 Apr;57(4):1051-1063. doi: 10.1002/ppul.25837. Epub 2022 Jan 28.

Effects of Freshly Irradiated vs Irradiated and Stored Red Blood Cell Transfusion on Cerebral Oxygenation in Preterm Infants: A Randomized Clinical Trial.

Saito-Benz M, Bennington K, Gray CL, Murphy WG, Flanagan P, Steiner F, Atkinson G, Berry MJ.JAMA Pediatr. 2022 May 1;176(5):e220152. doi: 10.1001/jamapediatrics.2022.0152. Epub 2022 May 2.

Vitamin K and the Newborn Infant.

Hand I, Noble L, Abrams SA.Pediatrics. 2022 Mar 1;149(3):e2021056036. doi: 10.1542/peds.2021-056036.PMID: 35190810

Sex Differences in the Association of Pretransfusion Hemoglobin Levels with Brain Structure and Function in the Preterm Infant.

Benavides A, Bell EF, Conrad AL, Feldman HA, Georgieff MK, Josephson CD, Koscik TR, Stowell SR, Sola-Visner M, Nopoulos P.J Pediatr. 2022 Apr;243:78-84.e5. doi: 10.1016/j.jpeds.2021.12.051. Epub 2021 Dec 27.

Neonatal anemia relates to intestinal injury in preterm infants.

Kalteren WS, Bos AF, van Oeveren W, Hulscher JBF, Kooi EMW.Pediatr Res. 2022 May;91(6):1452-1458. doi: 10.1038/s41390-021-01903-x. Epub 2021 Dec 14.

Enteral Iron Supplementation in Infants Born Extremely Preterm and its Positive Correlation with Neurodevelopment; Post Hoc Analysis of the Preterm Erythropoietin Neuroprotection Trial Randomized Controlled Trial.

German KR, Vu PT, Comstock BA, Ohls RK, Heagerty PJ, Mayock DE, Georgieff M, Rao R, Juul SE; PENUT Consortium.J Pediatr. 2021 Nov;238:102-109.e8. doi: 10.1016/j.jpeds.2021.07.019. Epub 2021 Jul 27.PMID: 34324880

Update on Phototherapy and Childhood Cancer in a Northern California Cohort.

Digitale JC, Kim MO, Kuzniewicz MW, Newman TB.Pediatrics. 2021 Nov;148(5):e2021051033. doi: 10.1542/peds.2021-051033. Epub 2021 Oct 29.PMID: 34716218

Bloodstream Infections in Preterm Neonates and Mortality-Associated Risk Factors.

https://www.jpeds.com/article/S0022-3476(21)00561-8/fulltext

Association of Blood Donor Sex and Age With Outcomes in Very Low-Birth-Weight Infants Receiving Blood Transfusion. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2783715

Urinary ferritin; a potential noninvasive way to screen NICU patients for iron deficiency.

Gerday E, Brereton JB, Bahr TM, Elmont JO, Fullmer S, Middleton BA, Ward DM, Ohls RK, Christensen RD.J Perinatol. 2021 Jun;41(6):1419-1425. doi: 10.1038/s41372-020-0746-6. Epub 2020 Jul 24.PMID: 32709979

Intravenous immunoglobulin G in the treatment of ABO hemolytic disease of the newborn during the early neonatal period at a tertiary academic hospital: a retrospective study.

Pan J, Zhan C, Yuan T, Chen X, Ni Y, Shen Y, Chen W, Wu T, Yu H.J Perinatol. 2021 Jun;41(6):1397-1402. doi: 10.1038/s41372-021-00963-5. Epub 2021 Feb 15.PMID: 33589732 Free PMC article.