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Gastroenterology

📑 Journal Club Articles

STAT trial: stoma or intestinal anastomosis for necrotizing enterocolitis: a multicentre randomized controlled trial.

Eaton S, Ganji N, Thyoka M, Shahroor M, Zani A, Pleasants-Terashita H, Ghazzaoui AE, Sivaraj J, Loukogeorgakis S, De Coppi P, Montedonico S, Sindjic-Antunovic S, Lukac M, Hamill J, Choo CSC, Nah SA, Hulscher J, Emil S, Petersen A, Wijnen R, Sloots C, Sigalet D, Kiely E, Svensson JF, Wester T, Pierro A.Pediatr Surg Int. 2024 Oct 29;40(1):279. doi: 10.1007/s00383-024-05853-3.PMID: 39470842 Free PMC article. Clinical Trial.

Timing of Red Blood Cell Transfusions and Occurrence of Necrotizing Enterocolitis: A Secondary Analysis of a Randomized Clinical Trial. 

Salas AA, Gunn E, Carlo WA, Bell EF, Das A, Josephson CD, Patel RM, Tan S, Kirpalani H; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network. JAMA Netw Open. 2024 May 1;7(5):e249643. doi: 10.1001/jamanetworkopen.2024.9643.

PMID: 38700862 

Breast Milk Enema and Meconium Evacuation Among Preterm Infants: A Randomized Clinical Trial. 

Zheng L, Gai L, Wu Y, Kong C, Sun F, Gao J, Yuan W, Liu M, Jiang H, Tuo N, Yang F.JAMA Netw Open. 2024 Apr 1;7(4):e247145. doi: 10.1001/jamanetworkopen.2024.7145.PMID: 38648060 Free article. Clinical Trial.

Effect of human milk-based fortification in extremely preterm infants fed exclusively with breast milk: a randomised controlled trial.

Jensen, G. B., Domellöf, M., Ahlsson, F., Elfvin, A., Navér, L., & Abrahamsson, T. eClinicalMedicine (2023).

Daily skin-to-skin contact alters microbiota development in healthy full-term infants.

Eckermann HA, Meijer J, Cooijmans K, Lahti L, de Weerth C.Gut Microbes. 2024 Jan-Dec;16(1):2295403. doi: 10.1080/19490976.2023.2295403. Epub 2024 Jan 10.PMID: 38197254 Free PMC article. Clinical Trial.

Early and exclusive enteral nutrition in infants born very preterm.

Razzaghy J, Shukla VV, Gunawan E, Reeves A, Nguyen K, Salas AA.Arch Dis Child Fetal Neonatal Ed. 2023 Dec 22:fetalneonatal-2023-325969. doi: 10.1136/archdischild-2023-325969. Online ahead of print.PMID: 38135494

The Irritable Infant in the Neonatal Intensive Care Unit: Risk Factors and Biomarkers of Gastroesophageal Reflux Disease.

Njeh M, Helmick R, Alshaikh E, Marcano K, Alexander A, Osborn E, Jadcherla SR.J Pediatr. 2023 Sep 29;264:113760. doi: 10.1016/j.jpeds.2023.113760. Online ahead of print.PMID: 37777170

Viral Infections and Neonatal Necrotizing Enterocolitis: A Meta-analysis.

Mani S, Hazra S, Hagan J, Sisson A, Nair J, Pammi M.Pediatrics. 2023 Jul 1;152(1):e2022060876. doi: 10.1542/peds.2022-060876.PMID: 37293714

Effects of prophylactic probiotics supplementation on infants born very preterm or very low birth weight.

Chiruvolu A, Hendrikson H, Hanson R, Reedy A, Reis J, Desai S, Suterwala M.J Perinatol. 2023 May;43(5):635-641. doi: 10.1038/s41372-023-01657-w. Epub 2023 Mar 30.PMID: 36997802

Are prophylactic anti-reflux medications effective after esophageal atresia repair? Systematic review and meta-analysis.

Miyake H, Chen Y, Hock A, Seo S, Koike Y, Pierro A.Pediatr Surg Int. 2018 May;34(5):491-497. doi: 10.1007/s00383-018-4242-4. Epub 2018 Mar 13.PMID: 29536176 Free PMC article. Review.

Antenatal Steroids, Prophylactic Indomethacin, and the Risk of Spontaneous Intestinal Perforation.

Laptook AR, Weydig H, Brion LP, Wyckoff MH, Arnautovic TI, Younge N, Oh W, Chowdhury D, Keszler M, Das A; National Institute of Child Health and Human Development Neonatal Research Network.J Pediatr. 2023 Aug;259:113457. doi: 10.1016/j.jpeds.2023.113457. Epub 2023 May 11.PMID: 37172814

Empirical Antimicrobial Therapy of Neonates with Necrotizing Enterocolitis: A Systematic Review.

Donà D, Gastaldi A, Barbieri E, Bonadies L, Aluvaala J, English M.Am J Perinatol. 2023 Apr;40(6):646-656. doi: 10.1055/s-0041-1730364. Epub 2021 Jun 14.PMID: 34126646 Free PMC article.

Current pain management practices for preterm infants with necrotizing enterocolitis: a European survey.

Ten Barge JA, van den Bosch GE, Meesters NJ, Allegaert K, Arribas C, Cavallaro G, Garrido F, Raffaeli G, Vermeulen MJ, Simons SHP; ESPR Special Interest Group for Neonatal Pain and the NEC Pain Study Group.Pediatr Res. 2023 Aug;94(2):555-563. doi: 10.1038/s41390-023-02508-2. Epub 2023 Feb 24.PMID: 36828969 Free PMC article.

Mucous fistula refeeding in neonates: a systematic review and meta-analysis.

Solís-García G, Jasani B.Arch Dis Child Fetal Neonatal Ed. 2023 Sep;108(5):523-529. doi: 10.1136/archdischild-2022-324995. Epub 2023 Mar 1.PMID: 36858828

Overuse of Reflux Medications in Infants.

Wolf ER, Sabo RT, Lavallee M, French E, Schroeder AR, Huffstetler AN, Schefft M, Krist AH.Pediatrics. 2023 Mar 1;151(3):e2022058330. doi: 10.1542/peds.2022-058330.PMID: 36756736

Antenatal Magnesium Sulfate and adverse gastrointestinal outcomes in Preterm infants-a systematic review and meta-analysis.

Prasath A, Aronoff N, Chandrasekharan P, Diggikar S.J Perinatol. 2023 Jun 30. doi: 10.1038/s41372-023-01710-8. Online ahead of print.PMID: 37391507 Review.

Dilemmas in feeding infants with intestinal failure: a neonatologist's perspective.

Hair AB, Good M.J Perinatol. 2023 Jan;43(1):114-119. doi: 10.1038/s41372-022-01504-4. Epub 2022 Sep 20.PMID: 36127395 Free PMC article. Review.

Variability in antibiotic duration for necrotizing enterocolitis and outcomes in a large multicenter cohort.

Ahmad I, Premkumar MH, Hair AB, Sullivan KM, Zaniletti I, Sharma J, Nayak SP, Reber KM, Padula M, Brozanski B, DiGeronimo R, Yanowitz TD; Children’s Hospitals Neonatal Consortium NEC Focus Group.J Perinatol. 2022 Nov;42(11):1458-1464. doi: 10.1038/s41372-022-01433-2. Epub 2022 Jun 27.

Mortality and neurodevelopmental outcomes of infants with spontaneous intestinal perforation: a systematic review and meta-analysis.

Ang JL, Rath CP, Tan H, Patole S, Rao SC.Arch Dis Child Fetal Neonatal Ed. 2023 May;108(3):256-266. doi: 10.1136/archdischild-2022-324157. Epub 2022 Nov 3.

Analysis of Neurodevelopment in Children Born Extremely Preterm Treated With Acid Suppressants Before Age 2 Years.

Jensen ET, Yi J, Jackson W, Singh R, Joseph RM, Kuban KCK, Msall ME, Washburn L, Fry R, South AM, O'Shea TM.JAMA Netw Open. 2022 Nov 1;5(11):e2241943. doi: 10.1001/jamanetworkopen.2022.41943.

Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation: A Multicenter Randomized Clinical Trial.

Blakely ML, Tyson JE, Lally KP, Hintz SR, Eggleston B, Stevenson DK, Besner GE, Das A, Ohls RK, Truog WE, Nelin LD, Poindexter BB, Pedroza C, Walsh MC, Stoll BJ, Geller R, Kennedy KA, Dimmitt RA, Carlo WA, Cotten CM, Laptook AR, Van Meurs KP, Calkins KL, Sokol GM, Sanchez PJ, Wyckoff MH, Patel RM, Frantz ID 3rd, Shankaran S, D'Angio CT, Yoder BA, Bell EF, Watterberg KL, Martin CA, Harmon CM, Rice H, Kurkchubasche AG, Sylvester K, Dunn JCY, Markel TA, Diesen DL, Bhatia AM, Flake A, Chwals WJ, Brown R, Bass KD, St Peter SD, Shanti CM, Pegoli W Jr, Skarda D, Shilyansky J, Lemon DG, Mosquera RA, Peralta-Carcelen M, Goldstein RF, Vohr BR, Purdy IB, Hines AC, Maitre NL, Heyne RJ, DeMauro SB, McGowan EC, Yolton K, Kilbride HW, Natarajan G, Yost K, Winter S, Colaizy TT, Laughon MM, Lakshminrusimha S, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health, Human Development Neonatal Research Network.Ann Surg. 2021 Oct 1;274(4):e370-e380. doi: 10.1097/SLA.0000000000005099.

Blood absolute monocyte count trends in preterm infants with suspected necrotizing enterocolitis: an adjunct tool for diagnosis?Moroze M, Morphew T, Sayrs LW, Eghbal A, Holmes WN, Shafer G, Mikhael M.
J Perinatol. 2024 Dec;44(12):1768-1773. doi: 10.1038/s41372-024-02070-7. Epub 2024 Aug 1.
PMID: 39090351

Long-Term Outcome of Necrotizing Enterocolitis and Spontaneous Intestinal Perforation.

Vaidya R, Yi JX, O'Shea TM, Jensen ET, Joseph RM, Shenberger J, Gogcu S, Wagner K, Msall ME, Thompson AL, Frazier JA, Fry R, Singh R; ELGAN-ECHO Study Investigators.Pediatrics. 2022 Nov 1;150(5):e2022056445. doi: 10.1542/peds.2022-056445.

A comparison of bacterial colonization between nasogastric and orogastric enteral feeding tubes in infants in the neonatal intensive care unit.

Vongbhavit K, Salinero LK, Kalanetra KM, Masarweh C, Yu A, Taft DH, Mills DA, Underwood MA.J Perinatol. 2022 Nov;42(11):1446-1452. doi: 10.1038/s41372-022-01452-z. Epub 2022 Jul 15.

Remote ischaemic conditioning in necrotising enterocolitis: a phase I feasibility and safety study.

Zozaya C, Ganji N, Li B, Janssen Lok M, Lee C, Koike Y, Gauda E, Offringa M, Eaton S, Shah PS, Pierro A.Arch Dis Child Fetal Neonatal Ed. 2023 Jan;108(1):69-76. doi: 10.1136/archdischild-2022-324174. Epub 2022 Aug 8.

Antibiotic exposure prevents acquisition of beneficial metabolic functions in the preterm infant gut microbiome.

Xu Y, Milburn O, Beiersdorfer T, Du L, Akinbi H, Haslam DB.Microbiome. 2022 Jul 7;10(1):103. doi: 10.1186/s40168-022-01300-4.

Effect of antibiotics in the first week of life on faecal microbiota development.

Van Daele E, Kamphorst K, Vlieger AM, Hermes G, Milani C, Ventura M, Belzer C, Smidt H, van Elburg RM, Knol J.Arch Dis Child Fetal Neonatal Ed. 2022 May 9;107(6):603-10. doi: 10.1136/archdischild-2021-322861. Online ahead of print.

Bifidobacteriumlongum subsp. infantis EVC001 Administration Is Associated with a Significant Reduction in the Incidence of Necrotizing Enterocolitis in Very Low Birth Weight Infants.

Tobias J, Olyaei A, Laraway B, Jordan BK, Dickinson SL, Golzarri-Arroyo L, Fialkowski E, Owora A, Scottoline B.J Pediatr. 2022 May;244:64-71.e2. doi: 10.1016/j.jpeds.2021.12.070. Epub 2022 Jan 12.

Glycerin Suppositories and Enemas in Premature Infants: A Meta-analysis.

Burchard PR, Lay R, Ruffolo LI, Ramazani SN, Walton JM, Livingston MH.Pediatrics. 2022 Apr 1;149(4):e2021053413. doi: 10.1542/peds.2021-053413.

Acetaminophen and Xenobiotic Metabolites in Human Milk and the Development of Bronchopulmonary Dysplasia and Retinopathy of Prematurity in a Cohort of Extremely Preterm Infants.

Santoro KL, Yakah W, Singh P, Ramiro-Cortijo D, Medina-Morales E, Freedman SD, Martin CR.J Pediatr. 2022 May;244:224-229.e3. doi: 10.1016/j.jpeds.2022.01.030. Epub 2022 Jan 31.

Delayed introduction of progressive enteral feeds to prevent necrotising enterocolitis in very low birth weight infants.

Morgan J, Young L, McGuire W. Cochrane Database Syst Rev. 2014;2014(12):CD001970. doi: 10.1002/14651858.CD001970.pub5. Epub 2014 Dec 1.

Neonatal anemia relates to intestinal injury in preterm infants.

Kalteren WS, Bos AF, van Oeveren W, Hulscher JBF, Kooi EMW.Pediatr Res. 2022 May;91(6):1452-1458. doi: 10.1038/s41390-021-01903-x. Epub 2021 Dec 14.

Effect of prophylactic dextrose gel on the neonatal gut microbiome.

St Clair SL, Harding JE, O'Sullivan JM, Gamble GD, Alsweiler JM, Vatanen T; hPOD Study Group.Arch Dis Child Fetal Neonatal Ed. 2022 Sep;107(5):501-507. doi: 10.1136/archdischild-2021-322757. Epub 2021 Dec 2.

Fortification of Breast Milk With Preterm Formula Powder vs Human Milk Fortifier in Preterm Neonates: A Randomized Noninferiority Trial.

Chinnappan A, Sharma A, Agarwal R, Thukral A, Deorari A, Sankar MJ.JAMA Pediatr. 2021 Aug 1;175(8):790-796. doi: 10.1001/jamapediatrics.2021.0678.PMID: 33970187 Free PMC article. Clinical Trial.

Respiratory Syncytial Virus Bronchiolitis Complicated by Necrotizing Enterocolitis: A Case Series.

Arias AV, Lucas DJ, Shafi NI.Pediatrics. 2021 May;147(5):e2020022707. doi: 10.1542/peds.2020-022707. Epub 2021 Apr 6.PMID: 33824182

Neonatology Review 
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